SARS-CoV-2 Variants

Virus variants
SARS-CoV-2 lineages - Visualisation of global virus lineages and reports of new variants (UK, South African and Brazilian)

Nextstrain.org SARS-CoV-2 genomic data (Global data)

Microreact SARS-CoV-2 genomic data visualisation (COG-UK)

Eric Topol. Summary table of UK, SA and Brazil variants (Twitter).

Florian Krammer. Vaccine-variant tweetorial

The Danish mink variant
Lassaunière R. et al. (Nov 2020) Working paper on SARS-CoV-2 spike mutations arising in Danish mink, their spread to humans and neutralization data. From Statens Serum Institute

The UK variant/strain Dec 2020 "VUI202012/01" B117
VUI - Variant Under Investigation

Russell P. (23 Dec 2020) New Variant of SARS-CoV-2 FAQs. Medscape UK.

Increased hazard of death in community-tested cases of SARS-CoV-2 Variant of Concern 202012/01 Nicholas G. Davies, Christopher I. Jarvis, CMMID COVID-19 Working Group, W. John Edmunds, Nicholas P. Jewell, Karla Diaz-Ordaz, Ruth H. Keogh medRxiv 2021.02.01.21250959; doi: https://doi.org/10.1101/2021.02.01.21250959

New and Emerging Respiratory Virus Threats Advisory Group (21 Jan 2021) NERVTAG note on B.1.1.7 severity - discusses B117 and mortality/disease severity

Baker L. (19 Dec 2020) Independent SAGE scientists share update as new mutation triggers today’s lockdown announcements. Healthcare Newsdesk.

Muik A et al. (19 Jan 2021) Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera. bioRxiv 2021.01.18.426984; doi: https://doi.org/10.1101/2021.01.18.426984 '' "These data, together with the combined immunity involving humoral and cellular effectors induced by this vaccine, make it unlikely that the B.1.1.7 lineage will escape BNT162b2-mediated protection." ''

Twitter discussion(s) Dr Eric Feigl-Ding: B117 and ?decrease in Pfizer vaccine efficacy

The South African variant "501Y.V2" B1135
Wibmer CK et al. (19 January 2021) SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma bioRxiv 2021.01.18.427166; doi: https://doi.org/10.1101/2021.01.18.427166

Twitter discussion(s) Dr Eric Feigl-Ding: B1135 and ?decrease in Pfizer vaccine efficacy

The Brazilian variant "501Y.V3" P1
Faria et al. (Jan 12 2021) Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings.

Variants with mixed mutations
Public Health England (21 Jan 2020) Investigation of novel SARS-CoV-2 variant Variant of Concern 202012/01: Technical briefing 5.

"The spike protein mutation E484K (found in VOC 202012/02 B1.351 and VOC 202101/02 P1) has been detected in 11 B1.1.7 sequences. Preliminary information suggests more than one acquisition event."