SARS-CoV-2 and COVID-19

General
BMJ Best Practice: COVID-19 - expert advice contributions by Nick Beeching from Liverpool School of Hygiene and Tropical Medicine, Tom Fletcher and Robert Fowler : includes criteria/case definitions and treatment algorithm

This page by Nature curates key new research relevant to COVID-19

Presentation
COVID Symptom Study (17 July 2020) The COVID Symptom Study reveals six distinct ‘types’ of COVID-19. COVID Symptom Study/ZOE/KCLAvailable from: https://covid.joinzoe.com/post/covid-clusters[Accessed: 16 August 2020]Sudre C. H. et al. (16 June 2020)

Symptom clusters in Covid19: A potential clinical prediction tool from the COVID Symptom study app. MedRxivdoi:https://doi.org/10.1101/2020.06.12.20129056 Available from: https://www.medrxiv.org/content/10.1101/2020.06.12.20129056v1[Accessed: 16 August 2020]

Dermatology
Galván Casas, C. et al. (29 April 2020) Classification of the cutaneous manifestations of COVID‐19: a rapid prospective nationwide consensus study in Spain with 375 cases. British Journal of Dermatology 2020;183pg.71-77 doi: https://doi.org/10.1111/bjd.19163 Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.19163[Accessed: 25August 2020]

Antibody testing
Deeks JJ.et al. (25 June 2020) '''Antibody tests for identification of current and past infection withSARS-CoV-2 (Review). Cochrane Database of Systematic Reviews''', Issue 6. Art. No.: CD013652.doi: https://doi.org/10.1002/14651858.CD013652 Availablefrom: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013652/full[Accessed: 16 August 2020]

Lisba Bastos M. et al. (1 July 2020) Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis. BMJ370:m2516 doi:https://doi.org/10.1136/bmj.m2516Available from:https://www.bmj.com/content/370/bmj.m2516[Accessed: 16 August 2020]Staines H. M. et al. (9 June 2020)

Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections. MedRxivdoi:https://doi.org/10.1101/2020.06.07.20124636 Available from: https://www.medrxiv.org/content/10.1101/2020.06.07.20124636v2[Accessed: 16 August 2020]

Viral shedding and live viral culture studies
[https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30172-5/fulltext?fbclid=IwAR3vs-r3apgaBb3wl1b00_jQnXZ9o5fnRoA4PY5sx0DX8oix-7Bisj7fhEY Lancet Review. SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis. Cevik et al. November 19, 2020] DOI:https://doi.org/10.1016/S2666-5247(20)30172-5 “Our findings suggest that, although patients with SARS-CoV-2 infection might have prolonged RNA shedding of up to 83 days in upper respiratory tract infection, no live virus was isolated from culture beyond day 9 of symptoms despite persistently high viral RNA loads."

[https://www.medrxiv.org/content/10.1101/2020.08.04.20167932v4 '''Viral cultures for COVID-19 infectivity assessment. Systematic review''' Tom Jefferson, Elizabeth Spencer, Jon Brassey, Carl Heneghan medRxiv 2020.08.04.20167932] doi: https://doi.org/10.1101/2020.08.04.20167932